PyGTK provides Python bindings for the GTK+ toolkit. Like the GTK+ library itself, it is currently licensed under the GNU LGPL. It is worth noting that PyGTK only currently supports the Gtk-2.X API (NOT Gtk-3.0). It is currently recommended that PyGTK not be used for new projects and that existing applications be ported from PyGTK to PyGObject.
PyGObject aka (PyGi)
Kivy is a Python library for development of multi-touch enabled media rich applications. The aim is to allow for quick and easy interaction design and rapid prototyping, while making your code reusable and deployable.
Kivy is written in Python, based on OpenGL and supports different input devices such as: Mouse, Dual Mouse, TUIO, WiiMote, WM_TOUCH, HIDtouch, Apple’s products and so on.
Kivy is actively being developed by a community and is free to use. It operates on all major platforms (Linux, OSX, Windows, Android).
The main resource for information is the website: http://kivy.org
Only available on OS X. Don’t pick this if you’re writing a cross-platform application.
PySide is a Python binding of the cross-platform GUI toolkit Qt.
pip install pyside
If your software does not fully comply with the GPL you will need a commercial license!
PyQt provides Python bindings for the Qt Framework (see below).
PyjamasDesktop (pyjs Desktop)
PyjamasDesktop is a port of Pyjamas. PyjamasDesktop is application widget set for desktop and a cross-platform framework. (After release v0.6 PyjamasDesktop is a part of Pyjamas (Pyjs)). Briefly, it allows the exact same Python web application source code to be executed as a standalone desktop application.
The main website; pyjs Desktop.
Qt is a cross-platform application framework that is widely used for developing software with a GUI but can also be used for non-GUI applications.
Tkinter is a thin object-oriented layer on top of Tcl/Tk. It has the advantage of being included with the Python standard library, making it the most convenient and compatible toolkit to program with.
Both Tk and Tkinter are available on most Unix platforms, as well as on Windows and Macintosh systems. Starting with the 8.0 release, Tk offers native look and feel on all platforms.
wxPython is a GUI toolkit for the Python programming language. It allows Python programmers to create programs with a robust, highly functional graphical user interface, simply and easily. It is implemented as a Python extension module (native code) that wraps the popular wxWidgets cross platform GUI library, which is written in C++.
Install (Stable) wxPythongo to http://www.wxpython.org/download.php#stable and download the appropriate package for your OS.
Article original from: http://docs.python-guide.org/en/latest/scenarios/gui/#gtk